[PSI(+)] yeast. containing the misfolded amyloid conformation of Sup35 prion. is cured by inactivation of Hsp104. There has been controversy as to whether inactivation of Hsp104 by guanidine treatment or by overexpression of the dominant negative Hsp104 mutant. https://www.caspbabyers.shop/product-category/activity-toys/