The routine prediction of three-dimensional protein structure from sequence remains a challenge in computational biochemistry. It has been intuited that calculated energies from physics-based scoring functions are able to distinguish native from nonnative folds based on previous performance with small proteins and that conformational sampling is the fundamental bottleneck to successfu... https://www.roneverhart.com/Jim-Beam-Liquor-Filled-Chocolate-Bottles-12-Piece-Box/